Author: MIT News

New exhibits showcase trailblazing MIT women

by Brigham Fay | MIT Libraries |

This spring, two new exhibits on campus are shining a light on the critical contributions of pathbreaking women at the Institute. They are part of MIT Libraries’ Women@MIT Archival Initiative in the Department of Distinctive Collections. Launched in 2017, the initiative not only adds to the historical record by collecting and preserving the papers of MIT-affiliated women, it shares their lives and work with global audiences through exhibits, multimedia projects, educational materials, and more.

Under the Lens

“Under the Lens: Women Biologists and Chemists at MIT 1865-2024,” examines the work of women in science and engineering at MIT beginning with Ellen Swallow Richards, the Institute’s first female student and instructor, through the present day, when a number of women with backgrounds in biology, biological engineering, chemistry, and chemical engineering — the subjects of focus in this exhibit — hold leadership positions at the Institute, including President Sally Kornbluth, Vice Provost for Faculty Paula Hammond, and Professor Amy Keating, who heads the Department of Biology.

Exhibit curator Thera Webb, Women@MIT project archivist, explains the exhibit title’s double meaning: “The women featured in ‘Under the Lens’ are scientists whose work engages with the materials of our world on a molecular level, using the lens of a microscope,” she says. “The title also plays on the fact that women’s ability to work as scientists and academics has been scrutinized through the lens of public opinion since Victorian-era debates about co-education.”

Items for the exhibit, selected from Distinctive Collections, demonstrate the experiences of women students, research staff, and faculty. They include the 1870 handwritten faculty meeting notes admitting Richards, then Ellen Henrietta Swallow, as MIT’s first female student, stating “the Faculty are of the opinion that the admission of women as special students is as yet in the nature of an experiment.” Materials from alumna and late professor ChoKyun Rha’s “Rheological Characterization of Printing Ink,” circa 1979, include images of the development process of ink and data from experiments. Also on display are a lab coat and rodent brain tissue slides from the neuroscience laboratory of Susan Hockfield, MIT’s 16th president.

“The collections we have related to women at MIT not only show us what their academic and professional interests were, with items like lab notebooks and drafts of papers, but also how our MIT community has been actively supporting women in science,” says Webb. “Many of our alumnae and faculty have been involved with the founding of groups like the Association of American University Women, the MIT Women’s Association, the Association for Women in Science, and the Women in Chemistry Group.”

“Under the Lens: Women Biologists and Chemists at MIT 1865-2024” is on view in the Maihaugen Gallery (Room 14N-130) through June 21. There is an accompanying digital exhibit available on the MIT Libraries’ website.

Sisters in Making

“Sisters in Making: Prototyping and the Feminine Resilience,” on view in Rotch Library, explores the unseen women, often referred to as “weavers,” who were instrumental to the development of computers. The exhibit, the work of Deborah Tsogbe SM ’23 and Soala Ajienka, a current architecture graduate student, spotlights the women who built the core rope memory and magnetic core memory for the Apollo Guidance Computer.

“While we ultimately know the names of the first men on the Moon, and of those who spearheaded the engineering initiatives behind the Apollo 11 mission, the names of the countless women who had a vital hand in realizing these feats have been missing from historical discourse,” Tsogbe and Ajienka write. “The focus of our work has been to uncover the names and faces of these women, who held important positions including overseeing communications, checking codes, running calculations, and weaving memory.”

Working in the archives, Tsogbe and Ajienka sought to identify the women involved in this endeavor, going through personnel logs, press releases, and other historical artifacts. Originally focused on the women working on rope memory, they broadened the scope of women involved in the journey to the moon and were able to name 534 women across 29 classes of work and nine organizations. Tsogbe and Ajienka fabricated a core memory prototype with the names of some of these women stored; they were technicians, data key punchers, engineers, librarians, and office staff from MIT, Raytheon, and NASA. Called the “memory dialer,” the prototype is intended to be a living archive.

Tsogbe and Ajienka created “Sisters in Making” as 2023 Women@MIT Fellows. This fellowship invites scholars, artists, and others to showcase materials from Distinctive Collections in engaging ways that contribute to greater understanding of the history of women at MIT and in STEM. The project also received a grant from the Council for the Arts at MIT.

“Deborah and Soala’s exhibit shows the variety of ways that the rich materials in the Women@MIT collections can be used,” says Webb. “Projects like these really highlight the value of historical collections in ways outside of traditional scholarly publications.”

“Sisters in Making: Prototyping and the Feminine Resilience” is on view in Rotch Library (Room 7-238) through April 8.

School of Science announces 2024 Infinite Expansion Awards

by School of Science |

The MIT School of Science has announced nine postdocs and research scientists as recipients of the 2024 Infinite Expansion Award, which highlights extraordinary members of the MIT community.

The following are the 2024 School of Science Infinite Expansion winners:

  • Sarthak Chandra, a research scientist in the Department of Brain and Cognitive Sciences, was nominated by Professor Ila Fiete, who wrote, “He has expanded the research abilities of my group by being a versatile and brilliant scientist, by drawing connections with a different area that he was an expert in from his PhD training, and by being a highly involved and caring mentor.”
  • Michal Fux, a research scientist in the Department of Brain and Cognitive Sciences, was nominated by Professor Pawan Sinha, who wrote, “She is one of those figurative beams of light that not only brilliantly illuminate scientific questions, but also enliven a research team.”
  • Andrew Savinov, a postdoc in the Department of Biology, was nominated by Associate Professor Gene-Wei Li, who wrote, “Andrew is an extraordinarily creative and accomplished biophysicist, as well as an outstanding contributor to the broader MIT community.”
  • Ho Fung Cheng, a postdoc in the Department of Chemistry, was nominated by Professor Jeremiah Johnson, who wrote, “His impact on research and our departmental community during his time at MIT has been outstanding, and I believe that he will be a worldclass teacher and research group leader in his independent career next year.”
  • Gabi Wenzel, a postdoc in the Department of Chemistry, was nominated by Assistant Professor Brett McGuire, who wrote, “In the one year since Gabi joined our team, she has become an indispensable leader, demonstrating exceptional skill, innovation, and dedication in our challenging research environment.”
  • Yu-An Zhang, a postdoc in the Department of Chemistry, was nominated by Professor Alison Wendlandt, who wrote, “He is a creative, deep-thinking scientist and a superb organic chemist. But above all, he is an off-scale mentor and a cherished coworker.”
  • Wouter Van de Pontseele, a senior postdoc in the Laboratory for Nuclear Science, was nominated by Professor Joseph Formaggio, who wrote, “He is a talented scientist with an intense creativity, scholarship, and student mentorship record. In the time he has been with my group, he has led multiple facets of my experimental program and has been a wonderful citizen of the MIT community.”
  • Alexander Shvonski, a lecturer in the Department of Physics, was nominated by Assistant Professor Andrew Vanderburg, who wrote, “… I have been blown away by Alex’s knowledge of education research and best practices, his skills as a teacher and course content designer, and I have been extremely grateful for his assistance.”
  • David Stoppel, a research scientist in The Picower Institute for Learning and Memory, was nominated by Professor Mark Bear and his research group, who wrote, “As impressive as his research achievements might be, David’s most genuine qualification for this award is his incredible commitment to mentorship and the dissemination of knowledge.”

Winners are honored with a monetary award and will be celebrated with family, friends, and nominators at a later date, along with recipients of the Infinite Mile Award.

Eight from MIT named 2024 Sloan Research Fellows

by School of Science |

Eight members of the MIT faculty are among 126 early-career researchers honored with 2024 Sloan Research Fellowships by the Alfred P. Sloan Foundation. Representing the departments of Chemistry, Electrical Engineering and Computer Science, and Physics, and the MIT Sloan School of Management, the awardees will receive a two-year, $75,000 fellowship to advance their research.

“Sloan Research Fellowships are extraordinarily competitive awards involving the nominations of the most inventive and impactful early-career scientists across the U.S. and Canada,” says Adam F. Falk, president of the Alfred P. Sloan Foundation. “We look forward to seeing how fellows take leading roles shaping the research agenda within their respective fields.”

Jacob Andreas is an associate professor in the Department of Electrical Engineering and Computer Science (EECS) as well as the Computer Science and Artificial Intelligence Laboratory (CSAIL). His research aims to build intelligent systems that can communicate effectively using language and learn from human guidance. Jacob has been named a Kavli Fellow by the National Academy of Sciences, and has received the NSF CAREER award, MIT’s Junior Bose and Kolokotrones teaching awards, and paper awards at ACL, ICML and NAACL.

Adam Belay, Jamieson Career Development Associate Professor of EECS in CSAIL, focuses on operating systems and networking, specifically developing practical and efficient methods for microsecond-scale distributed computing, which has many applications pertaining to resource management in data centers. His operating system, Caladan, reallocates server resources on a microsecond scale, resulting in high CPU utilization with low tail latency. Additionally, Belay has contributed to load balancing, and Application-Integrated Far Memory in OS designs.

Soonwon Choi, assistant professor of physics, is a researcher in the Center for Theoretical Physics, a division of the Laboratory for Nuclear Science. His research is focused on the intersection of quantum information and out-of-equilibrium dynamics of quantum many-body systems, specifically exploring the dynamical phenomena that occur in strongly interacting quantum many-body systems far from equilibrium and designing their novel applications for quantum information science. Recent contributions from Choi, recipient of the Inchon Award, include the development of simple methods to benchmark the quality of analog quantum simulators. His work allows for efficiently and easily characterizing quantum simulators, accelerating the goal of utilizing them in studying exotic phenomena in quantum materials that are difficult to synthesize in a laboratory.

Maryam Farboodi, the Jon D. Gruber Career Development Assistant Professor of Finance in the MIT Sloan School of Management, studies the economics of big data. She explores how big data technologies have changed trading strategies and financial outcomes, as well as the consequences of the emergence of big data for technological growth in the real economy. She also works on developing methodologies to estimate the value of data. Furthermore, Farboodi studies intermediation and network formation among financial institutions, and the spillovers to the real economy. She is also interested in how information frictions shape the local and global economic cycles.

Lina Necib PhD ’17, an assistant professor of physics and a member of the MIT Kavli Institute for Astrophysics and Space Research, explores the origin of dark matter through a combination of simulations and observational data that correlate the dynamics of dark matter with that of the stars in the Milky Way. She has investigated the local dynamic structures in the solar neighborhood using the Gaia satellite, contributed to building a catalog of local accreted stars using machine learning techniques, and discovered a new stream called Nyx. Necib is interested in employing Gaia in conjunction with other spectroscopic surveys to understand the dark matter profile in the local solar neighborhood, the center of the galaxy, and in dwarf galaxies.

Arvind Satyanarayan in an assistant professor of computer science and leader of the CSAIL Visualization Group. Satyanarayan uses interactive data visualization as a petri dish to study intelligence augmentation, asking how computational representations and software systems help amplify our cognition and creativity while respecting our agency. His work has been recognized with an NSF CAREER award, best paper awards at academic venues such as ACM CHI and IEEE VIS, and honorable mentions among practitioners including Kantar’s Information is Beautiful Awards. Systems he helped develop are widely used in industry, on Wikipedia, and in the Jupyter/Python data science communities.

Assistant professor of physics and a member of the Kavli Institute Andrew Vanderburg explores the use of machine learning, especially deep neural networks, in the detection of exoplanets, or planets which orbit stars other than the sun. He is interested in developing cutting-edge techniques and methods to discover new planets outside of our solar system, and studying the planets we find to learn their detailed properties. Vanderburg conducts astronomical observations using facilities on Earth like the Magellan Telescopes in Chile as well as space-based observatories like the Transiting Exoplanet Survey Satellite and the James Webb Space Telescope. Once the data from these telescopes are in hand, they develop new analysis methods that help extract as much scientific value as possible.

Xiao Wang is a core institute member of the Broad Institute of MIT and Harvard, and the Thomas D. and Virginia Cabot Assistant Professor of Chemistry. She started her lab in 2019 to develop and apply new chemical, biophysical, and genomic tools to better probe and understand tissue function and dysfunction at the molecular level. Specifically, with in situ sequencing of nucleic acids as the core approach, Wang aims to develop high-resolution and highly-multiplexed molecular imaging methods across multiple scales toward understanding the physical and chemical basis of brain wiring and function. She is the recipient of a Packard Fellowship, NIH Director’s New Innovator Award, and is a Searle Scholar.

Study unlocks nanoscale secrets for designing next-generation solar cells

by David L. Chandler | MIT News |

Perovskites, a broad class of compounds with a particular kind of crystal structure, have long been seen as a promising alternative or supplement to today’s silicon or cadmium telluride solar panels. They could be far more lightweight and inexpensive, and could be coated onto virtually any substrate, including paper or flexible plastic that could be rolled up for easy transport.

In their efficiency at converting sunlight to electricity, perovskites are becoming comparable to silicon, whose manufacture still requires long, complex, and energy-intensive processes. One big remaining drawback is longevity: They tend to break down in a matter of months to years, while silicon solar panels can last more than two decades. And their efficiency over large module areas still lags behind silicon. Now, a team of researchers at MIT and several other institutions has revealed ways to optimize efficiency and better control degradation, by engineering the nanoscale structure of perovskite devices.

The study reveals new insights on how to make high-efficiency perovskite solar cells, and also provides new directions for engineers working to bring these solar cells to the commercial marketplace. The work is described today in the journal Nature Energy, in a paper by Dane deQuilettes, a recent MIT postdoc who is now co-founder and chief science officer of the MIT spinout Optigon, along with MIT professors Vladimir Bulovic and Moungi Bawendi, and 10 others at MIT and in Washington state, the U.K., and Korea.

“Ten years ago, if you had asked us what would be the ultimate solution to the rapid development of solar technologies, the answer would have been something that works as well as silicon but whose manufacturing is much simpler,” Bulovic says. “And before we knew it, the field of perovskite photovoltaics appeared. They were as efficient as silicon, and they were as easy to paint on as it is to paint on a piece of paper. The result was tremendous excitement in the field.”

Nonetheless, “there are some significant technical challenges of handling and managing this material in ways we’ve never done before,” he says. But the promise is so great that many hundreds of researchers around the world have been working on this technology. The new study looks at a very small but key detail: how to “passivate” the material’s surface, changing its properties in such a way that the perovskite no longer degrades so rapidly or loses efficiency.

“The key is identifying the chemistry of the interfaces, the place where the perovskite meets other materials,” Bulovic says, referring to the places where different materials are stacked next to perovskite in order to facilitate the flow of current through the device.

Engineers have developed methods for passivation, for example by using a solution that creates a thin passivating coating. But they’ve lacked a detailed understanding of how this process works — which is essential to make further progress in finding better coatings. The new study “addressed the ability to passivate those interfaces and elucidate the physics and science behind why this passivation works as well as it does,” Bulovic says.

The team used some of the most powerful instruments available at laboratories around the world to observe the interfaces between the perovskite layer and other materials, and how they develop, in unprecedented detail. This close examination of the passivation coating process and its effects resulted in “the clearest roadmap as of yet of what we can do to fine-tune the energy alignment at the interfaces of perovskites and neighboring materials,” and thus improve their overall performance, Bulovic says.

While the bulk of a perovskite material is in the form of a perfectly ordered crystalline lattice of atoms, this order breaks down at the surface. There may be extra atoms sticking out or vacancies where atoms are missing, and these defects cause losses in the material’s efficiency. That’s where the need for passivation comes in.

“This paper is essentially revealing a guidebook for how to tune surfaces, where a lot of these defects are, to make sure that energy is not lost at surfaces,” deQuilettes says. “It’s a really big discovery for the field,” he says. “This is the first paper that demonstrates how to systematically control and engineer surface fields in perovskites.”

The common passivation method is to bathe the surface in a solution of a salt called hexylammonium bromide, a technique developed at MIT several years ago by Jason Jungwan Yoo PhD ’20, who is a co-author of this paper, that led to multiple new world-record efficiencies. By doing that “you form a very thin layer on top of your defective surface, and that thin layer actually passivates a lot of the defects really well,” deQuilettes says. “And then the bromine, which is part of the salt, actually penetrates into the three-dimensional layer in a controllable way.” That penetration helps to prevent electrons from losing energy to defects at the surface.

These two effects, produced by a single processing step, produces the two beneficial changes simultaneously. “It’s really beautiful because usually you need to do that in two steps,” deQuilettes says.

The passivation reduces the energy loss of electrons at the surface after they have been knocked loose by sunlight. These losses reduce the overall efficiency of the conversion of sunlight to electricity, so reducing the losses boosts the net efficiency of the cells.

That could rapidly lead to improvements in the materials’ efficiency in converting sunlight to electricity, he says. The recent efficiency records for a single perovskite layer, several of them set at MIT, have ranged from about 24 to 26 percent, while the maximum theoretical efficiency that could be reached is about 30 percent, according to deQuilettes.

An increase of a few percent may not sound like much, but in the solar photovoltaic industry such improvements are highly sought after. “In the silicon photovoltaic industry, if you’re gaining half of a percent in efficiency, that’s worth hundreds of millions of dollars on the global market,” he says. A recent shift in silicon cell design, essentially adding a thin passivating layer and changing the doping profile, provides an efficiency gain of about half of a percent. As a result, “the whole industry is shifting and rapidly trying to push to get there.” The overall efficiency of silicon solar cells has only seen very small incremental improvements for the last 30 years, he says.

The record efficiencies for perovskites have mostly been set in controlled laboratory settings with small postage-stamp-size samples of the material. “Translating a record efficiency to commercial scale takes a long time,” deQuilettes says. “Another big hope is that with this understanding, people will be able to better engineer large areas to have these passivating effects.”

There are hundreds of different kinds of passivating salts and many different kinds of perovskites, so the basic understanding of the passivation process provided by this new work could help guide researchers to find even better combinations of materials, the researchers suggest. “There are so many different ways you could engineer the materials,” he says.

“I think we are on the doorstep of the first practical demonstrations of perovskites in the commercial applications,” Bulovic says. “And those first applications will be a far cry from what we’ll be able to do a few years from now.” He adds that perovskites “should not be seen as a displacement of silicon photovoltaics. It should be seen as an augmentation — yet another way to bring about more rapid deployment of solar electricity.”

“A lot of progress has been made in the last two years on finding surface treatments that improve perovskite solar cells,” says Michael McGehee, a professor of chemical engineering at the University of Colorado who was not associated with this research. “A lot of the research has been empirical with the mechanisms behind the improvements not being fully understood. This detailed study shows that treatments can not only passivate defects, but can also create a surface field that repels carriers that should be collected at the other side of the device. This understanding might help further improve the interfaces.”

The team included researchers at the Korea Research Institute of Chemical Technology, Cambridge University, the University of Washington in Seattle, and Sungkyunkwan University in Korea. The work was supported by the Tata Trust, the MIT Institute for Soldier Nanotechnologies, the U.S. Department of Energy, and the U.S. National Science Foundation.

With just a little electricity, MIT researchers boost common catalytic reactions

by David L. Chandler | MIT News |

A simple technique that uses small amounts of energy could boost the efficiency of some key chemical processing reactions, by up to a factor of 100,000, MIT researchers report. These reactions are at the heart of petrochemical processing, pharmaceutical manufacturing, and many other industrial chemical processes.

The surprising findings are reported today in the journal Science, in a paper by MIT graduate student Karl Westendorff, professors Yogesh Surendranath and Yuriy Roman-Leshkov, and two others.

“The results are really striking,” says Surendranath, a professor of chemistry and chemical engineering. Rate increases of that magnitude have been seen before but in a different class of catalytic reactions known as redox half-reactions, which involve the gain or loss of an electron. The dramatically increased rates reported in the new study “have never been observed for reactions that don’t involve oxidation or reduction,” he says.

The non-redox chemical reactions studied by the MIT team are catalyzed by acids. “If you’re a first-year chemistry student, probably the first type of catalyst you learn about is an acid catalyst,” Surendranath says. There are many hundreds of such acid-catalyzed reactions, “and they’re super important in everything from processing petrochemical feedstocks to making commodity chemicals to doing transformations in pharmaceutical products. The list goes on and on.”

“These reactions are key to making many products we use daily,” adds Roman-Leshkov, a professor of chemical engineering and chemistry.

But the people who study redox half-reactions, also known as electrochemical reactions, are part of an entirely different research community than those studying non-redox chemical reactions, known as thermochemical reactions. As a result, even though the technique used in the new study, which involves applying a small external voltage, was well-known in the electrochemical research community, it had not been systematically applied to acid-catalyzed thermochemical reactions.

People working on thermochemical catalysis, Surendranath says, “usually don’t consider” the role of the electrochemical potential at the catalyst surface, “and they often don’t have good ways of measuring it. And what this study tells us is that relatively small changes, on the order of a few hundred millivolts, can have huge impacts — orders of magnitude changes in the rates of catalyzed reactions at those surfaces.”

“This overlooked parameter of surface potential is something we should pay a lot of attention to because it can have a really, really outsized effect,” he says. “It changes the paradigm of how we think about catalysis.”

Chemists traditionally think about surface catalysis based on the chemical binding energy of molecules to active sites on the surface, which influences the amount of energy needed for the reaction, he says. But the new findings show that the electrostatic environment is “equally important in defining the rate of the reaction.”

The team has already filed a provisional patent application on parts of the process and is working on ways to apply the findings to specific chemical processes. Westendorff says their findings suggest that “we should design and develop different types of reactors to take advantage of this sort of strategy. And we’re working right now on scaling up these systems.”

While their experiments so far were done with a two-dimensional planar electrode, most industrial reactions are run in three-dimensional vessels filled with powders. Catalysts are distributed through those powders, providing a lot more surface area for the reactions to take place. “We’re looking at how catalysis is currently done in industry and how we can design systems that take advantage of the already existing infrastructure,” Westendorff says.

Surendranath adds that these new findings “raise tantalizing possibilities: Is this a more general phenomenon? Does electrochemical potential play a key role in other reaction classes as well? In our mind, this reshapes how we think about designing catalysts and promoting their reactivity.”

Roman-Leshkov adds that “traditionally people who work in thermochemical catalysis would not associate these reactions with electrochemical processes at all. However, introducing this perspective to the community will redefine how we can integrate electrochemical characteristics into thermochemical catalysis. It will have a big impact on the community in general.”

While there has typically been little interaction between electrochemical and thermochemical catalysis researchers, Surendranath says, “this study shows the community that there’s really a blurring of the line between the two, and that there is a huge opportunity in cross-fertilization between these two communities.”

Westerndorff adds that to make it work, “you have to design a system that’s pretty unconventional to either community to isolate this effect.” And that helps explain why such a dramatic effect had never been seen before. He notes that even their paper’s editor asked them why this effect hadn’t been reported before. The answer has to do with “how disparate those two ideologies were before this,” he says. “It’s not just that people don’t really talk to each other. There are deep methodological differences between how the two communities conduct experiments. And this work is really, we think, a great step toward bridging the two.”

In practice, the findings could lead to far more efficient production of a wide variety of chemical materials, the team says. “You get orders of magnitude changes in rate with very little energy input,” Surendranath says. “That’s what’s amazing about it.”

The findings, he says, “build a more holistic picture of how catalytic reactions at interfaces work, irrespective of whether you’re going to bin them into the category of electrochemical reactions or thermochemical reactions.” He adds that “it’s rare that you find something that could really revise our foundational understanding of surface catalytic reactions in general. We’re very excited.”

“This research is of the highest quality,” says Costas Vayenas, a professor of engineering at the university of Patras, in Greece, who was not associated with the study. The work “is very promising for practical applications, particularly since it extends previous related work in redox catalytic systems,” he says.

The team included MIT postdoc Max Hulsey PhD ’22 and graduate student Thejas Wesley PhD ’23, and was supported by the Air Force Office of Scientific Research and the U.S. Department of Energy Basic Energy Sciences.

MIT community members honored with 2024 Franklin Institute Awards

by Department of Chemical Engineering |

The Franklin Institute recently announced its 2024 cohort of award winners, as part of its bicentennial celebration. Since its inception, the Franklin Institute Awards Program has honored the most influential scientists, engineers, and inventors who have significantly advanced science and technology. It is one of the oldest comprehensive science awards in the world.

The 2024 honorees include Institute Professor and Vice Provost for Faculty Paula T. Hammond ’84 PhD ’93; Associate Professor Gabriela S. Schlau-Cohen; Research Affiliate Robert Metcalfe ’69; Mary Boyce SM ’84, PhD ’87; and Lisa Su ’90, SM ’91, PhD ’94. All 2024 Franklin Institute Award Laureates will be celebrated in a ceremony on April 18 at the Benjamin Franklin National Memorial of the Franklin Institute.

Paula Hammond was awarded the 2024 Benjamin Franklin Medal in Chemistry, one of the oldest comprehensive science awards in the world. The award cites her “innovative methods to create novel materials one molecular layer at a time and for applying these materials to areas ranging from drug delivery to energy storage.” Hammond’s techniques for creating thin polymer films and other materials using layer-by-layer assembly is groundbreaking. They can be used to build polymers with highly controlled architectures by alternately exposing a surface to positively and negatively charged particles. Materials can then be designed for many different applications, including drug delivery, regenerative medicine, noninvasive imaging, and battery technologies. Hammond is the recipient of MIT’s 2023-24 Killian Award and, in 2021, was named an Institute Professor, MIT’s highest faculty honor. Hammond is one of only 25 people who have been elected to all three U.S. National Academies — Engineering, Science, and Medicine.

Gabriela Schlau-Cohen earned the Benjamin Franklin NextGen Award for “illuminating the fundamental chemical processes that protect plants from sun damage, uncovering novel approaches to increasing crop yields.” Schlau-Cohen combines tools from chemistry, optics, biology, and microscopy to develop new approaches to probe dynamics. Her group focuses on dynamics in membrane proteins, particularly photosynthetic light-harvesting systems that are of interest for sustainable energy applications. Following a postdoc at Stanford University, Schlau-Cohen joined the Department of Chemistry faculty in 2015. She earned a bachelor’s degree in chemical physics from Brown University in 2003 followed by a PhD in chemistry at the University of California at Berkeley.

Robert Metcalfe ’69, a research affiliate of the MIT Computer Science and Artificial Intelligence Laboratory and MIT Corporation life member emeritus, won the Benjamin Franklin Medal in Electrical Engineering for “his pioneering role in the design, development, and commercialization of Ethernet, an interface for networking and file sharing between computers.” MetCalfe is a graduate of MIT’s Department of Electrical Engineering and Computer Science (EECS) and is a former president of the MIT Alumni Association.

Mary Boyce SM ’84, PhD ’87 won the Benjamin Franklin Medal in Mechanical Engineering for “transformative contributions to our understanding of the physical behavior of polymers, materials made of long chains of molecules, leading to innovative product development of rubber and other soft materials.” A longtime MIT faculty member and former head of MIT’s Department of Mechanical Engineering, Boyce is currently a professor of mechanical engineering and provost emerita of Columbia University.

Lisa Su ’90, SM ’91, PhD ’94, a graduate of MIT’s Department of EECS and the current president, CEO, and chair of AMD, won the Bower Award for Business Leadership for “her transformational leadership of AMD, a leader in high-performance and adaptive computing and one of the fastest growing semiconductor companies in the world.”

Middle-school students meet a beam of electrons, and excitement results

by Lauren Paul | Department of Materials Science and Engineering |

Want to get middle-school kids excited about science? Let them do their own experiments on MIT.nano’s state-of-the-art microscopes — with guidelines and adult supervision, of course. That was the brainchild of Carl Thrasher and Tao Cai, MIT graduate students who spearheaded the Electron Microscopy Elevating Representation and Growth in Education (EMERGE) program.

Held in November, EMERGE invited 18 eighth-grade students to the pilot event at MIT.nano, an interdisciplinary facility for nanoscale research, to get hands-on experience in microscopy and materials science.

The highlight of the two-hour workshop: Each student explored mystery samples of everyday materials using one of two scanning electron microscopes (SEMs), which scan material samples using a beam of electrons to form an image. Though highly sophisticated, the instruments generated readily understandable data — images of intricate structures in a butterfly wing or a strand of hair, for example.

The students had an immediate, tangible sense of success, says Thrasher, from MIT’s Department of Materials Science and Engineering (DMSE). He led the program along with Cai, also from DMSE, and Collette Gordon, a grad student in the Department of Chemistry.

“This experience helped build a sense of agency and autonomy around this area of science, nurturing budding self-confidence among the students,” Thrasher says. “We didn’t give the students instructions, just empowered them to solve problems. When you don’t tell them the solution, you get really surprised with what they come up with.”

Unlocking interest in the infinitesimal

The students were part of a multi-year science and engineering exploration program called MITES Saturdays, run by MIT Introduction to Technology, Engineering, and Science, or MITES. A team of volunteers was on hand to help students follow the guidance set out by Thrasher, ensuring the careful handling of the SEMs — worth roughly $500,000 each.

MITES Saturdays program administrator Lynsey Ford was thrilled to observe the students’ autonomous exploration and enthusiasm.

“Our students got to meet real scientists who listened to them, cared about the questions they were asking, and welcomed them into a world of science,” Ford says. “A supportive learning environment can be just as powerful for science discovery as a half-million-dollar microscope.”

The pilot workshop was the first step for Thrasher and his team in their goal to build EMERGE into a program with broad impact, engaging middle-to-high school students from a variety of communities.

The partnership with MITES Saturdays is crucial for this endeavor, says Thrasher, providing a platform to reach a wider audience. “Seeing students from diverse backgrounds participating in EMERGE reinforces the profound difference science education can have.”

MITES Saturdays students are high-achieving Massachusetts seventh through 12th graders from Boston, MIT’s hometown of Cambridge, and nearby Lawrence.

“The majority of students who participate in our programs would be the first person in their family to go to college. A lot of them are from families balancing some sort of financial hardship, and from populations that are historically underrepresented in STEM,” Ford says.

Experienced SEM users set up the instruments and prepared test samples so students could take turns exploring specimens such as burrs, butterfly wings, computer chips, hair, and pollen by operating the microscope to adjust magnification, focus, and stage location.

Students left the EMERGE event with copies of the electron microscope images they generated. Thrasher hopes they will use these materials in follow-up projects, ideally integrating them into existing school curricula so students can share their experiences.

EMERGE co-director Cai says students were excited with their experimentation, both in being able to access such high-end equipment and in seeing what materials like Velcro look like under an SEM (spoiler alert: it’s spaghetti).

“We definitely saw a spark,” Cai says. “The subject matter was complex, but the students always wanted to know more.” And the after-program feedback was positive, with most saying the experience was fun and challenging. The volunteers noted how engaged the students were with the SEMs and subject matter. One volunteer overheard students say, “I felt like a real scientist!”

Inspiring tomorrow’s scientists

EMERGE is based on the Scanning Electron Microscopy Educators program, a long-running STEM outreach program started in 1991 by the Air Force Research Laboratory and adopted by Michigan State University. As an Air Force captain stationed at Wright-Patterson Air Force Base in Ohio, Thrasher participated in the program as a volunteer SEM expert.

“I thought it was an incredible opportunity for young students and wanted to bring it here to MIT,” he says.

The pilot was made possible thanks to support from the MITES Saturdays team and the Graduate Materials Council (GMC), the DMSE graduate student organization. Cai and DMSE grad student Jessica Dong, who are both GMC outreach chairs, helped fund, organize, and coordinate the event.

The MITES Saturdays students included reflections on their experience with the SEMs in their final presentations at the MITES Fall Symposium in November.

“My favorite part of the semester was using the SEM as it introduced me to microscopy at the level of electrons,” said one student.

“Our students had an incredible time with the EMERGE team. We’re excited about the possibility of future partnerships with MIT.nano and other departments at MIT, giving our scholars exposure to the breadth of opportunities as future scientists,” says Eboney Hearn, MITES executive director.

With the success of the pilot, the EMERGE team is looking to offer more programs to the MITES students in the spring. Anna Osherov is excited to give students more access to the cumulative staff knowledge and cutting-edge equipment at MIT.nano, which opened in 2018. Osherov is associate director for Characterization.nano, a shared experimental facility for advanced imaging and analysis.

“Our mission is to support mature researchers — and to help inspire the future PhDs and professors who will come to MIT to learn, research, and innovate,” Osherov says. “Designing and offering such programs, aimed at fostering natural curiosity and creativity of young minds, has a tremendous long-term benefit to our society. We can raise tomorrow’s generation in a better way.”

For her part, Ford is still coasting on the students’ excitement. “They come into the program so curious and hungry for knowledge. They remind me every day how amazing the world is.”

Susan Solomon wins VinFuture Award for Female Innovators

by Paige Colley | EAPS |

Lee and Geraldine Martin Professor of Environmental Studies Susan Solomon has been awarded the 2023 VinFuture Award for Female Innovators. Solomon was picked out of almost 1,400 international nominations across four categories for “The discovery of the ozone depletion mechanism in Antarctica, contributing to the establishment of the Montreal Protocol.” The award, which comes with a $500,000 prize, highlights outstanding female researchers and innovators that can serve as role models for aspiring scientists.

“I’m tremendously humbled by that, and I’ll do my best to live up to it,” says Solomon, who attended the ceremony in Hanoi, Vietnam, on Dec. 20.

The VinFuture Awards are given annually to “honor scientific research and breakthrough technological innovations that can make a significant difference” according to their site. In addition to Female Innovators, the award has two other special categories, Innovators from Developing Countries and Innovators with Outstanding Achievements in Emerging Fields, as well as their overall grand prize. The awards have been given out by the Vietnam-based VinFuture Foundation since 2021.

“Countries all around the world are part of scientific progress and innovation, and that a developing country is honoring that is really very lovely,” says Solomon, whose career as an atmospheric chemist has brought her onto the international stage and has shown her firsthand how important developing countries are in crafting global policy.

In 1986 Solomon led an expedition of 16 scientists to Antarctica to measure the degradation of the ozone layer; she was the only woman on the team. She and her collaborators were able to figure out the atmospheric chemistry of chlorofluorocarbons and other similar chemicals that are now known as ozone-depleting substances. This work became foundational to the creation of the Montreal Protocol, an international agreement that banned damaging chemicals and has allowed the ozone to recover.

Solomon joined the MIT faculty in 2012 and holds joint appointments in the departments of Chemistry and Earth, Atmospheric and Planetary Sciences. The success of the Montreal Protocol demonstrates the ability for international cooperation to enact effective environmental agreements; Solomon sees it as a blueprint for crafting further policy when it comes to addressing global climate change.

“Women can do anything, even help save the ozone layer and solve other environmental problems,” she says. “Today’s problem of climate change is for all of us to be involved in solving.”

Performance art and science collide as students experience “Blue Man Group”

by Danielle Doughty | Department of Chemistry |

On a blustery December afternoon, with final exams and winter break on the horizon, the 500 undergraduate students enrolled in Professor Bradley Pentelute’s Course 5.111 (Principles of Chemical Science) class were treated to an afternoon at the theater — a performance of “Blue Man Group” at Boston’s Charles Playhouse — courtesy of Pentelute and the MIT Office of the First Year.

Theatrical thrills aside, it was Blue Man Group’s practical application of chemical principles that inspired Pentelute to initiate and fund this excursion. The MIT Office of the First Year was pleased to collaborate with him to support an opportunity for first-year students to interact with one another outside of the classroom by providing funding for 300 of the tickets and T passes for all.

“By observing the use of specialized paints and materials in the show, students gain a deeper understanding of how chemistry intersects with creative expression,” says Pentelute. “This unique experience is inspired by our discussions on the chemistry of pigments and the role of chemistry in everyday life, aiming to bridge theoretical knowledge with real-world applications. The visit served as an engaging opportunity to enhance [the group’s] learning and foster a sense of community within our class.”

A fixture in Boston’s theater district since 1995, “Blue Man Group” is a euphoric, multi-sensory performance featuring three silent “Blue Men” who interact with the audience and one another not with words, but with art, music, comedy, and non-verbal communication. The characters are other-worldly in their innocence, appearing mystified by the audience and the most commonplace of objects. No two performances are completely alike, as the Blue Men pull members of the audience on stage, make music with instruments fashioned out of construction and plumbing materials, and, possibly most notably, drums covered in liquid paint that splash all over everything — and everyone — in what is known as the Poncho Zone.

The Charles Playhouse has a capacity of 500 seats, so the audience of this particular show was made up entirely of MIT undergraduate students — any tickets not utilized by 5.111 students were offered to first-generation first-year students. The experience proved to be an exciting example of practical applications of the general chemistry concepts and undergraduate camaraderie.

Catherine Hazard, a Department of Chemistry graduate student and the teaching assistant for 5.111, was one of the many attendees thrilled to see science in action at the theater.

“The use of brightly colored oil paints, a hallmark of the show, was a direct representation of chemical structures and crystal field theory concepts covered in class,” explains Hazard. “We learned how energy splitting of d orbitals influences color of varying inorganic transition metal complexes, as well as how chemicals such as waxes, resins, polymers, and stabilizers give the oil paint the proper consistency for the performance. The event was a fun culmination of the lessons learned just before heading into a week of finals.”

The goal of the Office of the First Year is to provide excellent services and programs to catalyze student exploration and access to opportunity, and promote the academic success and personal development of undergraduates. Programs and experiences like this one serve to enrich and support undergraduate education at MIT.

Pentelute joined the MIT faculty in 2011. His research group in the Department of Chemistry develops new protein modification chemistries, adapts nature’s machines for efficient macromolecule delivery into cells, invents flow technologies for rapid biopolymer production, and discovers peptide binders to proteins.

A new drug candidate can shrink kidney cysts

by Anne Trafton | MIT News |

Autosomal dominant polycystic kidney disease (ADPKD), the most common form of polycystic kidney disease, can lead to kidney enlargement and eventual loss of function. The disease affects more than 12 million people worldwide, and many patients end up needing dialysis or a kidney transplant by the time they reach their 60s.

Researchers at MIT and Yale University School of Medicine have now found that a compound originally developed as a potential cancer treatment holds promise for treating ADPKD. The drug works by exploiting kidney cyst cells’ vulnerability to oxidative stress — a state of imbalance between damaging free radicals and beneficial antioxidants.

In a study employing two mouse models of the disease, the researchers found that the drug dramatically shrank kidney cysts without harming healthy kidney cells.

“We really believe this has potential to impact the field and provide a different treatment paradigm for this important disease,” says Bogdan Fedeles, a research scientist and program manager in MIT’s Center for Environmental Health Sciences and the lead author of the study, which appears this week in the Proceedings of the National Academy of Sciences.

John Essigmann, the William R. and Betsy P. Leitch Professor of Biological Engineering and Chemistry at MIT; Sorin Fedeles, executive director of the Polycystic Kidney Disease Outcomes Consortium and assistant professor (adjunct) at Yale University School of Medicine; and Stefan Somlo, the C.N.H. Long Professor of Medicine and Genetics and chief of nephrology at Yale University School of Medicine, are the senior authors of the paper.

Cells under stress

ADPKD typically progresses slowly. Often diagnosed when patients are in their 30s, it usually doesn’t cause serious impairment of kidney function until patients reach their 60s. The only drug that is FDA-approved to treat the disease, tolvaptan, slows growth of the cysts but has side effects that include frequent urination and possible liver damage.

Essigmann’s lab did not originally set out to study PKD; the new study grew out of work on potential new drugs for cancer. Nearly 25 years ago, MIT research scientist Robert Croy, also an author of the new PNAS study, designed compounds that contain a DNA-damaging agent known as an aniline mustard, which can induce cell death in cancer cells.

In the mid 2000s, Fedeles, then a grad student in Essigmann’s lab, along with Essigmann and Croy, discovered that in addition to damaging DNA, these compounds also induce oxidative stress by interfering with mitochondria — the organelles that generate energy for cells.

Tumor cells are already under oxidative stress because of their abnormal metabolism. When they are treated with these compounds, known as 11beta compounds, the additional disruption helps to kill the cells. In a study published in 2011, Fedeles reported that treatment with 11beta compounds significantly suppressed the growth of prostate tumors implanted in mice.

A conversation with his brother, Sorin Fedeles, who studies polycystic kidney disease, led the pair to theorize that these compounds might also be good candidates for treating kidney cysts. At the time, research in ADPKD was beginning to suggest that kidney cyst cells also experience oxidative stress, due to an abnormal metabolism that resembles that of cancer cells.

“We were talking about a mechanism of what would be a good drug for polycystic kidney disease, and we had this intuition that the compounds that I was working with might actually have an impact in ADPKD,” Bogdan Fedeles says.

The 11beta compounds work by disrupting the mitochondria’s ability to generate ATP (the molecules that cells use to store energy), as well as a cofactor known as NADPH, which can act as an antioxidant to help cells neutralize damaging free radicals. Tumor cells and kidney cyst cells tend to produce increased levels of free radicals because of the oxidative stress they’re under. When these cells are treated with 11beta compounds, the extra oxidative stress, including the further depletion of NADPH, pushes the cells over the edge.

“A little bit of oxidative stress is OK, but the cystic cells have a low threshold for tolerating it. Whereas normal cells survive treatment, the cystic cells will die because they exceed the threshold,” Essigmann says.

Shrinking cysts

Using two different mouse models of ADPKD, the researchers showed that 11beta-dichloro could significantly reduce the size of kidney cysts and improve kidney function.

The researchers also synthesized a “defanged” version of the compound called 11beta-dipropyl, which does not include any direct DNA-damaging ability and could potentially be safer for use in humans. They tested this compound in the early-onset model of PKD and found that it was as effective as 11beta-dichloro.

In all of the experiments, healthy kidney cells did not appear to be affected by the treatment. That’s because healthy cells are able to withstand a small increase in oxidative stress, unlike the diseased cells, which are highly susceptible to any new disturbances, the researchers say. In addition to restoring kidney function, the treatment also ameliorated other clinical features of ADPKD; biomarkers for tissue inflammation and fibrosis were decreased in the treated mice compared to the control animals.

The results also suggest that in patients, treatment with 11beta compounds once every few months, or even once a year, could significantly delay disease progression, and thus avoid the need for continuous, burdensome antiproliferative therapies such as tolvaptan.

“Based on what we know about the cyst growth paradigm, you could in theory treat patients in a pulsatile manner — once a year, or perhaps even less often — and have a meaningful impact on total kidney volume and kidney function,” Sorin Fedeles says.

The researchers now hope to run further tests on 11beta-dipropyl, as well as develop ways to produce it on a larger scale. They also plan to explore related compounds that could be good drug candidates for PKD.

Other MIT authors who contributed to this work include Research Scientist Nina Gubina, former postdoc Sakunchai Khumsubdee, former postdoc Denise Andrade, and former undergraduates Sally S. Liu ’20 and co-op student Jake Campolo. The research was funded by the PKD Foundation, the U.S. Department of Defense, the National Institutes of Health, and the National Institute of Environmental Health Sciences through the Center for Environmental Health Sciences at MIT.