Research in the Buchwald Group combines elements of organic synthesis, physical organic chemistry and organometallic chemistry to devise catalytic processes of use in solving problems of fundamental importance.
The central focus of the Chakraborty Group is to understand the mechanistic underpinnings of the adaptive immune response to pathogens, and harness this understanding to help design better vaccines and therapies.
Current investigations in our laboratory focus on the development of new synthetic methods and strategies, and their application in the total synthesis of natural products and biologically important compounds.
By combining X-ray crystallography, cryo-electron microscopy and other biophysical methods, the goal of the Drennan lab is to “visualize” molecular processes by obtaining snapshots of enzymes in action.
Employing a multidisciplinary approach involving synthesis, state-of-the-art spectroscopy, molecular modeling, enzymology, and molecular biology to address fundamental problems at the interface of chemistry and biology.
The mission of the Jamison group is to accelerate chemical synthesis through new reactions and technologies, particularly through the use of continuous flow synthesis, nickel-catalysis and epoxide-opening cascades.
Enzymatic catalysis in nonaqueous solvents, enzymes as stereoselective catalysts in organic synthesis, novel microbicidal materials, and the stabilization and delivery of macromolecular pharmaceuticals.
The focus of Professor Lippard's research is on the synthesis, reactions, physical and structural properties of metal complexes as models for the active sites of metalloproteins and as anti-cancer drugs.
The Pentelute Lab invents new protein modification chemistries, adapts Nature's biological machines for efficient drug delivery into cells, and creates new technologies to rapidly manufacture peptides and proteins.
Using techniques that range from synthetic chemistry to cell biology, the Raines group is illuminating in atomic detail both the chemical basis and the biological purpose for protein structure and protein function.
Professor Steinfeld's research interests evolved from focusing on obtaining kinetic data for physical and chemical systems using time-resolved spectroscopy, to ultimately studying gigaseconds and large, interconnected systems.
Our main objective is to understand the molecular chemistry that underlies global biogeochemical cycles, with the ultimate goal of deploying this knowledge to improve human health and positively impact the environment.
Broadly focused on synthetic, supramolecular, analytical, and materials chemistry, the Swager Group is interested in a spectrum of topics with an emphasis on the synthesis and construction of functional assemblies.
The Zhang Lab aims to build a global framework of the human genome that connects its sequence with structure and activity, and to enable quantitative and predictive modeling of genome structure and function.