The multidisciplinary research in the Peng group aims to elucidate the molecular mechanisms by which human diseases occur. We develop and integrate a diverse toolbox spanning single-molecule microscopy, super-resolution microscopy, spectroscopy, nanomaterial engineering, biophysics, chemical biology, and quantitative modeling to uncover previously unexplored biological processes. With bright and photostable probes, we have unprecedented capability to record ultralong-term “molecular movies” in living systems with high spatiotemporal resolutions and reveal molecular interactions that drive biological functions. We are particularly interested in studying molecular dynamics, protein-protein interactions, and cellular heterogeneity involved in neurobiology and cancer biology.
The Peng Laboratory develops optical imaging techniques and nanoprobes to enable long-term single-molecule imaging in living systems and reveal molecular interactions that are responsible for human diseases.