Research in the Buchwald Group combines elements of organic synthesis, physical organic chemistry and organometallic chemistry to devise catalytic processes of use in solving problems of fundamental importance.
The Ceyer group explores the atomic level dynamics of the interactions of molecules with surfaces of materials that serve as catalysts relevant to energy production and environmental sustainability or as templates for nanodevices.
The central focus of the Chakraborty Group is to understand the mechanistic underpinnings of the adaptive immune response to pathogens, and harness this understanding to help design better vaccines and therapies.
Current investigations in our laboratory focus on the development of new synthetic methods and strategies, and their application in the total synthesis of natural products and biologically important compounds.
By combining X-ray crystallography, cryo-electron microscopy and other biophysical methods, the goal of the Drennan lab is to “visualize” molecular processes by obtaining snapshots of enzymes in action.
Research in the Essigmann Group focuses on how repair enzymes remove structural damage from DNA and on how the adducts that evade repair either kill cells or induce mutations and cancer.
Tunable lasers, often two or three simultaneously, are used in Field's Current Research Group to investigate the structural and dynamical properties of small, gas phase molecules.
The Gilliard Lab is engaged in energy-relevant chemical synthesis at the interface of inorganic and organic chemistry that impacts the discovery of new chemical reagents and the design of redox-active and/or luminescent molecular materials.
A large fraction of the Griffin Group's research effort is devoted to the development of new magnetic resonance techniques to study molecular structure and dynamics
The Hong group develops and applies high-resolution solid-state NMR spectroscopy to elucidate the structure and dynamics of biological macromolecules, with an emphasis on membrane proteins.
Employing a multidisciplinary approach involving synthesis, state-of-the-art spectroscopy, molecular modeling, enzymology, and molecular biology to address fundamental problems at the interface of chemistry and biology.
The mission of the Jamison group is to accelerate chemical synthesis through new reactions and technologies, particularly through the use of continuous flow synthesis, nickel-catalysis and epoxide-opening cascades.
The Johnson Laboratory uses chemical and biophysical tools to understand and tune the activity of molecular chaperone proteins in protein misfolding diseases.
Enzymatic catalysis in nonaqueous solvents, enzymes as stereoselective catalysts in organic synthesis, novel microbicidal materials, and the stabilization and delivery of macromolecular pharmaceuticals.
The Kulik group leverages multi-scale modeling, electronic structure calculations, and machine learning for the discovery of new molecules and mechanisms in a range of materials from metal-organic frameworks to enzymes and organometallics.
The focus of Professor Lippard's research is on the synthesis, reactions, physical and structural properties of metal complexes as models for the active sites of metalloproteins and as anti-cancer drugs.
Research in the McGuire Group uses the tools of physical chemistry, molecular spectroscopy, and observational astrophysics to understand how the chemical ingredients for life evolve with and help shape the formation of stars and planets.
Our research is aimed at time-resolved optical study and control of condensed matter structural changes and the collective modes of motion through which they occur.
The Peng Laboratory develops optical imaging techniques and nanoprobes to enable long-term single-molecule imaging in living systems and reveal molecular interactions that are responsible for human diseases.
The Pentelute Lab develops new protein modification chemistries, adapts nature's machines for efficient macromolecule delivery into cells, invents flow technologies for rapid biopolymer production, and discovers peptide binders to proteins.
Research in the Radosevich group centers on the invention of new homogeneous catalysts and reagents based on inexpensive and earth-abundant elements of the p-block.
Using techniques that range from synthetic chemistry to cell biology, the Raines group is illuminating in atomic detail both the chemical basis and the biological purpose for protein structure and protein function.
Research in the Schlau-Cohen group is inherently multidisciplinary and combines tools from chemistry, optics, biology, and microscopy to develop new approaches to probe dynamics.
The Shalek Lab creates and implements new approaches to elucidate cellular and molecular features that inform tissue-level function and dysfunction across the spectrum of human health and disease.
The Shoulders Laboratory (1) studies how cells fold proteins and (2) develops and applies next-generation protein engineering and directed evolution techniques to address biotechnology challenges.
Professor Steinfeld's research interests evolved from focusing on obtaining kinetic data for physical and chemical systems using time-resolved spectroscopy, to ultimately studying gigaseconds and large, interconnected systems.
JoAnne Stubbe studies ribonucleotide reductases — essential enzymes that provide the building blocks for DNA replication, repair and successful targets of multiple clinical drugs.
Our main objective is to understand the molecular chemistry that underlies global biogeochemical cycles, with the ultimate goal of deploying this knowledge to improve human health and positively impact the environment.
The Surendranath Lab is focused on addressing global challenges in the areas of chemical catalysis, energy storage and utilization, and environmental stewardship.
Broadly focused on synthetic, supramolecular, analytical, and materials chemistry, the Swager Group is interested in a spectrum of topics with an emphasis on the synthesis and construction of functional assemblies.
The Van Voorhis Group is developing new methods – primarily based on density functional theory (DFT) – that provide an accurate description of excited electron motion in molecular systems.
Research in the Wendlandt Group focuses on the development of selective, catalytic reactions using the tools of organic/organometallic synthesis and physical organic chemistry.
The Zhang Lab aims to build a global framework of the human genome that connects its sequence with structure and activity, and to enable quantitative and predictive modeling of genome structure and function.