The paper, Robust gold nanorods stabilized by bidentate N-heterocyclic-carbene–thiolate ligands, was published online on November 12, 2018.
A paper authored by Michelle J. MacLeod, Aaron J. Goodman, Hong-Zhou Ye, Hung V.-T. Nguyen, Professor Troy Van Voorhis and Professor Jeremiah A. Johnson was published in Nature Chemistry on November 12, 2018.
Robust gold nanorods stabilized by bidentate N-heterocyclic-carbene–thiolate ligands
Michelle J. MacLeod, Aaron J. Goodman, Hong-Zhou Ye, Hung V.-T. Nguyen, Troy Van Voorhis & Jeremiah A. Johnson
Nature Chemistry, 12 November, 2018
Abstract: Although N-heterocyclic carbenes (NHCs) have demonstrated outstanding potential for use as surface anchors, synthetic challenges have limited their application to either large planar substrates or very small spherical nanoparticles. The development of a strategy to graft NHCs onto non-spherical nanomaterials, such as gold nanorods, would greatly expand their utility as surface ligands. Here, we use a bidentate thiolate–NHC–gold(i) complex that is easily grafted onto commercial cetyl trimethylammonium bromide-stabilized gold nanorods through ligand exchange. On mild reduction of the resulting surface-tethered NHC–gold(i) complexes, the gold atom attached to the NHC complex is added to the surface as an adatom, thereby precluding the need for reorganization of the underlying surface lattice upon NHC binding. The resulting thiolate–NHC-stabilized gold nanorods are stable towards excess glutathione for up to six days, and under conditions with large variations in pH, high and low temperatures, high salt concentrations, or in biological media and cell culture. We also demonstrate the utility of these nanorods for in vitro photothermal therapy.
The Johnson laboratory seeks creative, macromolecular solutions to problems at the interface of chemistry, medicine, biology, and materials science.
The Van Voorhis group is developing new methods – primarily based on density functional theory (DFT) – that provide an accurate description of excited electron motion in molecular systems.