Research in the Schlau-Cohen group is inherently multidisciplinary and combines tools from chemistry, optics, biology, and microscopy to develop new approaches to probe dynamics.

Office

Phone

617-253-1478

gssc@mit.edu

Administrative Assistant

Li Miao

Assistant Phone

617-452-2243

Lab Website

Gabriela S. Schlau-Cohen

Associate Professor of Chemistry

Research Areas

Office

6-225

Phone

617-253-1478

gssc@mit.edu

Administrative Assistant

Li Miao

Assistant Phone

617-452-2243

Lab Website

Research in our group is inherently multidisciplinary; we combine tools from chemistry, optics, biology, and microscopy to develop new approaches to probe dynamics. We study dynamics in two classes of systems: biological and bio-inspired light-harvesting systems that are of interest to solar energy research and biomass production; and bacterial and mammalian receptor proteins that are targets for human therapeutics. To explore these systems, we use ultrafast transient absorption spectroscopy, single-molecule fluorescence spectroscopy, and develop model membrane systems.

Key Publications

See all on the Schlau-Cohen Group Website

Identification of distinct pH-and zeaxanthin-dependent quenching in LHCSR3 from Chlamydomonas reinhardtii

J.M. Troiano, F. Perozeni, R. Moya, L. Zuliani, K. Baek, E. Jin, S. Cazzaniga, M. Ballottari, G.S. Schlau-Cohen. eLife ASAP (2021).

Full text at eLife

Engineering couplings for exciton transport using synthetic DNA scaffolds

S.M. Hart, W.J. Chen, J.L. Banal, W.P. Bricker, A. Dodin, L. Markova, Y. Vyborna, A.P. Willard, R. Haener, M. Bathe, G.S. Schlau-Cohen. Chem ASAP (2021).

Full text at Chem

Phosphorylation-Dependent Conformations of the Disordered Carboxyl-Terminus Domain in the Epidermal Growth Factor Receptor

R. Regmi, S. Srinivasan, A.P. Latham, V. Kukshal, W. Cui, B. Zhang, R. Bose, G.S. Schlau-Cohen. J. Phys. Chem. Lett. 11, 23 (2020).

Full Text at ACS Publications

Identification of Non-Radiative Decay Pathways in Cy3

S.M. Hart, J.L. Banal, M. Bathe, G.S. Schlau-Cohen. J. Phys. Chem. Lett. 11, 13 (2020)

Full Text at ACS Publications

Observation of dissipative chlorophyll-to-carotenoid energy transfer in light-harvesting complex II in membrane nanodiscs

M. Son, A. Pinnola, S.C. Gordon, R. Bassi, G.S. Schlau-Cohen. Nature Commun. 11, 1 (2020)

Full text at Nature Communications

Microsecond and millisecond dynamics in the photosynthetic protein LHCSR1 observed by single-molecule correlation spectroscopy

T. Kondo, J.B. Gordon, A. Pinnola, L. Dall’Osto, R. Bassi, G.S. Schlau-Cohen. Proc. Natl. Acad. Sci. 23, 11247 (2019).

Full text at PNAS

The Electronic Structure of Lutein 2 Is Optimized for Light Harvesting in Plants

M. Son, A. Pinnola, R. Bassi, G.S. Schlau-Cohen. Chem, 5, 575 (2019).

Full text at Chem

Single-molecule fluorescence detection of the epidermal growth factor receptor (EGFR) in membrane discs

S.D. Quinn, S. Srinivasan, J.B. Gordon, W. He, K.L. Carraway III, M.A. Coleman, G.S. Schlau-Cohen. Biochemistry, 58, 285 (2019).

Full Text at ACS Publications

Ultrabroadband 2D electronic spectroscopy with high-speed, shot-to-shot detection

M. Son, S. Mosquera-Vasquez, G. S. Schlau-Cohen, Opt Express, 25, 18950 (2017).

Full text at OSA Publishing

Single-Molecule Spectroscopy of LHCSR1 Protein Dynamics Identifies Two Distinct States Responsible for Multi-Timescale Photosynthetic Photoprotection

T. Kondo, A. Pinnola, W. J. Chen, L. Dall’Osto, R. Bassi, G. S. Schlau-Cohen, Nature Chem, 9, 772 (2017).

Full text at Nature Chemistry