The research in our group combines elements of organic synthesis, physical organic chemistry and organometallic chemistry to devise catalytic processes of use in solving problems of fundamental importance. In this way we invent or develop new techniques, determine how they proceed and apply them in a synthetically interesting context. The key to our success has been the extraordinary quality of the coworkers in the research group over the years.
Research in the Buchwald Group combines elements of organic synthesis, physical organic chemistry and organometallic chemistry to devise catalytic processes of use in solving problems of fundamental importance.
Office
18-490Phone
617-253-1885Administrative Assistant
Jeff TaftAssistant Phone
617-253-1830Office
18-490Phone
617-253-1885Administrative Assistant
Jeff TaftAssistant Phone
617-253-1830Key Publications
See all on the Buchwald Group WebsiteCatalytic Arylhydroxylation of Dehydroalanine in Continuous Flow for Simple Access to Unnatural Amino Acids
K. M. R. Khan, Zhao, Y. , Scully, T. , and Buchwald, S. L., Chem. Eur. J., 2018, Accepted Article.
Full text at Wiley Online LibraryA Modified System for the Synthesis of Enantioenriched N‐Arylamines through Copper‐Catalyzed Hydroamination
S. Ichikawa, Zhu, S. , and Buchwald, S. L., Angew. Chem. Int. Ed., 2018, 57, 8714-8718.
Full text at Wiley Online LibraryCuH‐Catalyzed Asymmetric Hydroamidation of Vinylarenes
Y. Zhou, Engl, O. D. , Bandar, J. S. , Chant, E. D. , and Buchwald, S. L., Angew. Chem. Int. Ed., 2018, 57, 6672-6675.
Full text at Wiley Online LibraryCopper-Catalyzed Enantioselective Hydroamination of Alkenes
R. Y. Liu and Buchwald, S. L., Org. Syn., 2018, 95, 80-96.
Full text at Organic SynthesisAsymmetric Cu-Catalyzed 1,4-Dearomatization of Pyridines and Pyridazines without Preactivation of the Heterocycle or Nucleophile
M. W. Gribble, Guo, S. , and Buchwald, S. L., J. Am. Chem. Soc., 2018, 140(15), 5057-5060.
Full text at JACSBreaking the Base Barrier: An Electron-Deficient Palladium Catalyst Enables the Use of a Common, Soluble Base in C–N Coupling
J. M. Dennis, White, N. A. , Liu, R. Y. , and Buchwald, S. L., J. Am. Chem. Soc., 2018, 140(13), 4721–4725.
Full text at JACSPalladium-Catalyzed C–O Cross-Coupling of Primary Alcohols
H. Zhang, Ruiz-Castillo, P. , and Buchwald, S. L., Org. Lett., 2018, 20, 1580-1583.
Full text at Organic LettersMolecular Design of Deep Blue Thermally Activated Delayed Fluorescence Materials Employing a Homoconjugative Triptycene Scaffold and Dihedral Angle Tuning
W. Huang, Einzinger, M. , Zhu, T. , Chae, H. Sik, Jeon, S. , Ihn, S. - G. , Sim, M. , Kim, S. , Su, M. , Teverovskiy, G. , Wu, T. , Van Voorhis, T. , Swager, T. M. , Baldo, M. A. , and Buchwald, S. L., Chem. Mater., 2018, 30(5), 1462–1466.
Full text at Chemistry of Materials