The central focus of the Chakraborty Group is to understand the mechanistic underpinnings of the adaptive immune response to pathogens, and harness this understanding to help design better vaccines and therapies.
By combining X-ray crystallography, cryo-electron microscopy and other biophysical methods, the goal of the Drennan lab is to “visualize” molecular processes by obtaining snapshots of enzymes in action.
Research in the Essigmann Group focuses on how repair enzymes remove structural damage from DNA and on how the adducts that evade repair either kill cells or induce mutations and cancer.
A large fraction of the Griffin Group's research effort is devoted to the development of new magnetic resonance techniques to study molecular structure and dynamics
The Hong group develops and applies high-resolution solid-state NMR spectroscopy to elucidate the structure and dynamics of biological macromolecules, with an emphasis on membrane proteins.
Employing a multidisciplinary approach involving synthesis, state-of-the-art spectroscopy, molecular modeling, enzymology, and molecular biology to address fundamental problems at the interface of chemistry and biology.
The Johnson Laboratory uses chemical and biophysical tools to understand and tune the activity of molecular chaperone proteins in protein misfolding diseases.
The Kulik group leverages multi-scale modeling, electronic structure calculations, and machine learning for the discovery of new molecules and mechanisms in a range of materials from metal-organic frameworks to enzymes and organometallics.
The Peng Laboratory develops optical imaging techniques and nanoprobes to enable long-term single-molecule imaging in living systems and reveal molecular interactions that are responsible for human diseases.
The Pentelute Lab develops new protein modification chemistries, adapts nature's machines for efficient macromolecule delivery into cells, invents flow technologies for rapid biopolymer production, and discovers peptide binders to proteins.
Using techniques that range from synthetic chemistry to cell biology, the Raines group is illuminating in atomic detail both the chemical basis and the biological purpose for protein structure and protein function.
Research in the Schlau-Cohen group is inherently multidisciplinary and combines tools from chemistry, optics, biology, and microscopy to develop new approaches to probe dynamics.
The Shalek Lab creates and implements new approaches to elucidate cellular and molecular features that inform tissue-level function and dysfunction across the spectrum of human health and disease.
The Shoulders Laboratory (1) studies how cells fold proteins and (2) develops and applies next-generation protein engineering and directed evolution techniques to address biotechnology challenges.
Our main objective is to understand the molecular chemistry that underlies global biogeochemical cycles, with the ultimate goal of deploying this knowledge to improve human health and positively impact the environment.