The central focus of the Chakraborty Group is to understand the mechanistic underpinnings of the adaptive immune response to pathogens, and harness this understanding to help design better vaccines and therapies.
By combining X-ray crystallography, cryo-electron microscopy and other biophysical methods, the goal of the Drennan lab is to “visualize” molecular processes by obtaining snapshots of enzymes in action.
Employing a multidisciplinary approach involving synthesis, state-of-the-art spectroscopy, molecular modeling, enzymology, and molecular biology to address fundamental problems at the interface of chemistry and biology.
The Pentelute Lab develops new protein modification chemistries, adapts nature's machines for efficient macromolecule delivery into cells, invents flow technologies for rapid biopolymer production, and discovers peptide binders to proteins.
Using techniques that range from synthetic chemistry to cell biology, the Raines group is illuminating in atomic detail both the chemical basis and the biological purpose for protein structure and protein function.
Our main objective is to understand the molecular chemistry that underlies global biogeochemical cycles, with the ultimate goal of deploying this knowledge to improve human health and positively impact the environment.