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Rows and rows of pink and turquoise circles with sketches of variations of p53.

Cancer’s Secret Safety Net

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Chemists determine the structure of the fuzzy coat that surrounds Tau proteins

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MIT chemists showed they can use nuclear magnetic resonance (NMR) to decipher the structure of the fuzzy coat that surrounds Tau proteins. The findings may aid efforts to develop drugs that interfere with Tau buildup in the brain.
“What’s remarkable is that intelectin-2 (mltln2) operates in two complementary ways. It helps stabilize the mucus layer, and if that barrier is compromised, it can directly neutralize or restrain bacteria that begin to escape,” says Laura Kiessling. On left, mltln2 stabilizes the mucus layer on healthy tissue. On right, it neutralizes bacteria in an inflamed GI tract.

A protein found in the GI tract can neutralize many bacteria

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