Chemistry is truly the central science and underpins much of the efforts of scientists and engineers to improve life for humankind. TheMIT Department of Chemistryis taking a leading role in discovering new chemical synthesis, catalysis, creating sustainable energy, theoretical and experimental understanding of chemistry, improving the environment, detecting and curing disease, developing materials new properties, and nanoscience.
The Chemistry Education Office staff is responsible for administering the educational programs in the Department of Chemistry. Students can find answers to many questions about the undergraduate and graduate programs on the department website, and they are encouraged to stop by and see the staff in the office located in 6-205.
The student-run outreach programs in the Department of Chemistry aim to bring the excitement of chemical sciences to the community through lively demonstrations designed to illustrate a broad range of chemical principles. Graduate students visit science classes in high schools and middle schools in the Greater Boston area with a view to demystifying chemistry through hands-on experiments. ClubChem, an undergraduate chemistry organization, conducts Chemistry Magic Shows for elementary schools and youth programs in the Greater Boston area.
Chemistry is truly the central science and underpins much of the efforts of scientists and engineers to improve life for humankind. MIT Chemistry is taking a leading role in discovering new chemical synthesis, catalysis, creating sustainable energy, theoretical and experimental understanding of chemistry at its most fundamental level, unraveling the biochemical complexities of natural systems, improving the environment, detecting and curing disease, developing materials new properties, and nanoscience.
A large fraction of our research effort is devoted to the development of new magnetic resonance techniques to study molecular structure and dynamics. Typical of the problems that we address is the design of experiments to measure 13C-13C and 13C-15N dipolar couplings, and therefore to perform spectral assignments and to measure internuclear distances and torsion angles, in solids from magic angle spinning (MAS) NMR spectra. This information leads directly to molecular structures of amyloid and membrane peptides and proteins (vide infra). In addition, we are developing high field dynamic nuclear polarization (DNP)/NMR experiments. The motivation behind this research is the possibility to obtain large nuclear spin polarizations, and therefore increased NMR signal intensities. The top figure at the left illustrates signal enhancements recorded from a sample of U(13C,15N) proline where we have observed a factor of ~20 larger signal strengths when the sample is doped with paramagnetic centers and irradiated with 250 GHz microwaves. The experiments have developed to the point where it is possible to record multiple dimensional spectra as illustrated in the middle panels of the figure. This increased signal intensities should enable many new applications to be addressed. As part of this project, we are also performing CW and pulsed EPR experiments at 140 GHz. For systems not susceptible to g-strain, the higher EPR frequencies offer considerably increased resolution and ease of interpretation of the spectral lineshapes. Finally, we are also involved in the development of approaches for investigating dynamic processes in solids. Generally, these experiments involve analysis of 2H NMR powder patterns, and details concerning the rates and mechanism of the motion are derived from the lineshapes.
The second major part of our research is the application of the magnetic resonance techniques described above to interesting chemical, biophysical, and physical problems. We are currently employing MAS NMR experiments to investigate the structure of large enzyme/inhibitor complexes, membrane proteins and amyloid peptide and proteins. By measuring chemical shifts and dipolar couplings between homonuclear and heteronuclear spin pairs in inhibitors or active sites, we have been able to address structural questions in several cases. For example, we have performed NMR on photochemical intermediates of bacteriorhodopsin trapped at low temperature to study the mechanism of proton pumping and the origin of the opsin shift in the optical spectrum of retinal in this protein. More recently we have completed the initial two structures of peptides with MAS dipole recoupling techniques. One of these, an 11-mer from the protein transthyretin, is illustrated in the bottom part of the figure and is the initial structure of a peptide in an amyloid fibril. Since these molecules do not diffract and are not soluble, their structures can only be determined by high resolution solid state NMR.